Genetically modified animals, due to their multiple and unique uses, are of the most important achievements in biotechnology. However, as they have feelings and perception the production of these animals should be done within a specific normative framework. The most important ethical approaches in this field can be regarded under three headings of free use, absolute prohibition and conditional use. The axe of ethical considerations in the latter approach is considering the two elements of waste and teasing animals (physical/psychological) in the process of genetic engineering on the one hand and to ensure a rational balance between said elements and rational objectives of genetically engineering on the other hand. The presence of the elements of waste and teasing animals can be investigated in two levels of production methods and applications of transgenic animals. In the level of methods, since we are to admit the presence of both elements waste and teasing during the genetic transferring process, the emphasis must be put on the need to use techniques having waste and teasing as less as possible. In the applications level as a general approach the laboratory and animal welfare conditions is considered to be important and also in certain teasing applications like disease models, scientific models and xenotransplantation, the use of effective methods of euthanasia is recommended.
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